Targeting IGF1/IGF1r signaling relieve pain and autophagic dysfunction in NTG-induced chronic migraine model of mice
Abstract Background Chronic migraine is a severe and common neurological disorder, yet its precise physiological mechanisms remain unclear.The IGF1/IGF1r signaling pathway plays a crucial role in pain modulation.Studies have shown that IGF1, by binding to its receptor IGF1r, activates a series of downstream signaling cascades involved in neuronal B